骨形态发生蛋白与非酒精性脂肪性肝病

Bone morphogenetic protein and non-alcoholic fatty liver disease

非酒精性脂肪性肝病是目前最常见的慢性肝脏疾病，是肝的代谢障碍表现。近年来研究发现，骨形态发生蛋白（BMP）家族（BMP-9、BMP一7及BMP一6等）与非酒精性脂肪性肝病密切相关，机制涉及铁过载、炎性反应、激活相关蛋白等，其有望成为治疗非酒精性脂肪性肝病的新靶点。

Non-alcoholic fatty liver disease is by far the most common chronic liver disease, is the metabolic disorders of liver. In recent years, studies have found that bone morphogenetic protein （BMP） family （BMP-9, BMP-7, BMP-6 and so on） was closely related to non-alcoholic fatty liver disease, its mech- anism involved iron overload, inflammatory response, activation of related proteins and so on. It is expected to be a new target for the treatment of non-alcoholic fatty liver disease.