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静滴头孢唑啉给药剂量、静注时间、血浓与疗效间的关系 被引量:1

Correlation of Dosage Infusion time Serum Concentration with Curative Effect of Cefazolin Administered by I.V. Infusion
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摘要 本文报道了三十例患者使用头孢唑啉2g、3g、4g、6g、8g不同剂量的静滴情况,并进行了血浓监测,分析了剂量、滴速、血浓与疗效间的关系。结果表明:对于一般轻度感染患者采用2g头孢唑啉置于250ml补液中静滴1~1.5h,一天二次;若病情严重,则可酌情增加剂量,采用3~4g头孢唑啉静滴,一天二次的治疗方案较为适宜。 This paper report the results from monitoring cefazolin's serum concentrationsin thirty patients, the dosages used were 2. 3. 4. 6 and 8g administered by I. V. in-fusion. then analysed the correlation of dosage, infusion rate, serum concentrationwith curative effect. The studies indicate, in mild infection 2g of cefazolin shouldbe dissolved in 250ml of a compatibal sterile intravenous solution and infused overa period of 1-1. 5h q12h. For serious cases, the dosage should be increased to 3-4gq12h depending on the severity of the infection.
出处 《中国医院药学杂志》 CAS CSCD 北大核心 1991年第8期367-369,共3页 Chinese Journal of Hospital Pharmacy
关键词 头孢唑啉 血药浓度 疗效 Cefazolin Serum concentration monitoring Correlation Therapeutic regimen
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