胺碘酮联合卡维地洛治疗心律失常的效果分析

Analysis of the effect of amiodarone combined with carvedilol in the treatment of arrhythmia

目的探讨胺碘酮联合卡维地洛治疗心律失常的效果。方法选取心律失常患者90例，按照用药情况的不同分为对照组和观察组，每组45例，对照组采用胺碘酮治疗，观察组在对照组的基础上加服卡维地洛，观察两组治疗效果。结果治疗前，两组收缩压[（149±11）mmHg比（151±14）mmHg）]、舒张压[（95±11）mmHg比（95±12）mmHg）]、心率[（143±16）次／min比（141±18）次／min]的平均水平差异均无统计学意义（t=1．245、2．568、3．228，均P〉0．05）；治疗后，观察组有效率（91．11％）、心律的转复率（88．89％）、达到治疗有效标准时间[（2．50±0．79）d]、收缩压[（119±12）mmHg]、舒张压[（78±12）mmHg]、心率[（78±20）次／min]均优于对照组[86．67％、75．56％、（5．62±3．16）d、（142±15）mmHg、（90±13）mmHg、（99±23）次／min]，两组差异均有统计学意义（Х^2=8．235、7．157，t=6．214、5．201、6．253、5．102，均P〈0．05）。结论胺碘酮联合卡维地洛治疗心律失常，能够明显改善心功能，控制血压、心率，抑制患者病情恶化，在临床治疗中可推广应用。

Objective To explore the effect of amiodarone combined with carvedilol in the treatment of patients with arrhythmia. Methods 90 patients with cardiac arrhythmia were selected. According to different treatment, the patients were divided into control group and observation group, 45 cases in each group. The control group was treated with amiodarone, the observation group was given amiodarone combined with carvedilol. The therapeutic effect of the two groups was observed. Results Before treatment, the systolic blood pressure [ （ 149 ± 11 ） mmHg vs. （ 151 ± 14 ） mmHg） ], diastolic blood pressure [ （ 95 ± 11 ） mmHg vs. （95 ± 12 ） mmHg） ], heart rate [ （143 ± 16）times/rain vs. （141 ± 18 ）times/mini between the two groups had no statistically significant differences （t = 6. 214, 1. 907,3. 228, all P 〉 0. 05 ）. After treatment, the effective rate （91. 11% ）, cardioversion rate （88.89%） ,standard time to achieve effective treatment [ （2.50 ± 0. 79） d], systolic blood pressure [ （ 119 ± 12） mmHg ], diastolic blood pressure [ （78 ± 12） mmHg ], heart rate [ （ 78 ± 20） times/min ] in the observation group were better than those in the control group [ 86.67%, 75.56%, （5.62 ± 3. 16 ） d, （ 142 ± 15 ） mmHg, （90 ± 13）mmHg, （99 ± 23 ）times/mini, and the differences between the two groups were statistically significant （Х^2 = 8. 235,7. 157,t = 6. 214,5. 718,5. 102, all P 〈 0.05）. Conclusion Carvedilol combined with amiodarone in the treatment of patients with abnormal heart rate can significantly improve the cardiac function, suppress deterioration, and can be widely used in clinical treatment.