程序性细胞死亡4在结直肠癌中的作用

Role of programmed cell death 4 in colorectal cancer

程序性细胞死亡4(programmed cell death 4,PDCD4)基因定位于染色体10q24,通过阻碍真核生物翻译起始因子复合物eIF4F合成,在转录和翻译水平抑制肿瘤发展。PDCD4基因在结直肠癌中的表达调节机制非常复杂,涉及多条信号转导通路,并影响肿瘤细胞增殖、侵袭、转移及耐药。该文综述了PDCD4在结直肠癌发展中分子机制、表达及预后判断等相关研究进展。

The programmed cell death 4（PDCD4） gene is located on chromosome 10q24 and inhibits tumor progression at transcriptional and translational levels by blocking the eukaryotic biological translation initiation factor complex eIF4F synthesis. The regulatory mechanism of PDCD4 gene expression in colorectal cancer（CRC） is sophisticated, by which involves multiple signal transduction pathways and affects the proliferation, invasion, metastasis and drug resistance of CRC cells. That review summarizes the molecular mechanisms, expression and prognosis of PDCD4 in the development of CRC.