热疗联合同步放化疗在局部晚期非小细胞肺癌中应用

Combination of thermotherapy and concurrent radiochemotherapy in locally advanced non-small cell lung cancer

目的观察热疗联合放化疗治疗局部晚期非小细胞肺癌(NSCLC)的疗效。方法 56例局部晚期NSCLC患者随机分为研究组(30例)和对照组(26例),分别给予同步放化疗+热疗、同步放化疗。比较两组近期疗效、生存质量及不良反应。结果与对照组比较,研究组治疗后3个月疗效、中位生存和疾病进展时间、1~2年生存率、生活质量评分均优于对照组(P<0.01或0.05),而骨髓抑制、胃肠道反应及肺毒性发生率差异无统计学意义(P>0.05)。结论热疗联合放化疗治疗局部晚期NSCLC近期疗效确切,可延长患者生存时间和提高生活质量。

Objective To observe the efficacy of thermotherapy and concurrent radiochemotherapy in locally advanced non-small cell lung cancer（NSCLC）. Methods Fifty-six patients with locally advanced NSCLC were randomly divided into observation（n=30） and control（n=26） groups, and treated with concurrent radiochemotherapy plus thermotherapy and concurrent radiochemotherapy, respectively. The short-term efficacy, quality of life（QOL）, and adverse reactions were compared between two groups. Results Compared with control group, 3-month efficacy, median survival and progression time, 1-and 2-year survival rate, and QOL were better in observation group（P〈0.01 or 0.05）, but myelosuppression,gastrointestinal reaction and radiation pneumonia showed no significant difference between two groups（P〈0.05）. Conclusion Combination of thermotherapy and concurrent radiochemotherapy is effective, and improve the survival time and QOL in patients with locally advanced NSCLC.