苄星青霉素驱梅治疗后无症状神经梅毒发病情况的临床分析

Clinical analysis of the morbidity of asymptomatic neurosyphilis after the treatment with benzathine penicillin

目的了解苄星青霉素治疗后无症状神经梅毒的发病情况。方法对490例苄星青霉素治疗后血清复发和固定者行脑脊液检测,以分析无症状神经梅毒的发病情况。结果 490例梅毒患者经全程足量苄星青霉素治疗甚至重复治疗,仍有46例患者有脑脊液异常且无任何临床症状。结论在梅毒的治疗随访中对血清复发、血清滴度不降或下降迟缓的现象,应及时行脑脊液检查,减少神经梅毒的发生。

Objective To understand the morbidity of asymptomatic neurosyphilis after the treatment with benzathine penicillin. Methods By testing cerebrospinal fluid of 490 syphilis cases of serum recurrence or fixation, who have been treated with benzathine penicillin, to analyze the prevalence of asymptomatic neurosyphilis. Results It showed that though full benzathine penicillin treatment or even repeated treatment had been used on these 490 cases of syphilitics, there were still 46 patients showed abnormal cerebrospinal fluid without any clinical symptoms. Conclusion During the follow-up of syphilis, according to the phenomenons like serum recurrence and serum titer standing or declining slowly, it is necessary to examine cerebrospinal fluid timely to reduce the occurrence of neurosyphilis.