HIF-1α与TREM-1在寻常性银屑病皮损中的表达及其意义

The Expression and Significance of TREM-1 and HIF-1α in Psoriasis Vulgaris Skin Lesion

目的探讨HIF-1α与TREM-1在寻常性银屑病发病中可能的作用机制。方法采用免疫组织化学与实时荧光定量PCR的方法检测缺氧诱导因子1α(HIF-1α)与髓样细胞触发受体-1(TREM-1)在寻常性银屑病与正常皮肤组织中的表达情况,并分析HIF-1α与TREM-1在银屑病组织中表达的相关关系。结果正常皮肤组织中HIF-1α与TREM-1主要表达于基底细胞层,在寻常性银屑病患者皮损中HIF-1α与TREM-1表达增加,主要表达于表皮全层,其表达水平差异具有统计学意义(P<0.05)。HIF-1αmRNA与TREM-1 mRNA在寻常性银屑病皮损表达均升高,与正常组织相比,差异具有统计学意义(P<0.05)。并且HIF-1α与TREM-1在寻常性银屑病组织中表达呈正相关(P<0.05)。结论 HIF-1α与TREM-1在寻常性银屑病的异常表达可能参与了寻常性银屑病发生、发展,并在此过程中存在共同路径,TREM-1可能成为治疗寻常性银屑病的潜在靶点。

Objective To discuss potential pathogenesis of HIF-1α and TREM-1 in psoriasis.Methods Immunohischemistry and realtime-PCR were used to detect expression of HIF-1α and TREM-1 in normal skins and psoriasis lesions,and the relationship between TREM-1 and HIF-1α in psoriasis were analyzed.Results The expression of HIF-1α and TREM-1 were limited to stratum basele in normal skin,while they expressed in the psoriasis lesions,however, in the whole epidermis.The expression levels of HIF-1α and TREM-1 in psoriatic lesions were significantly higher than that in normal tissues（P〈0.05）.Moreover,the expression of HIF-1α was positively correlated with the expression of TREM-1 in psoriasis vulgaris（P〈0.05）.Conclusion The higher expression of HIF-1α and TREM-1 which participate in the same mechanism may play an important role in pathogenesis of psoriasis.Therefore, TREM-1 will be the potential therapeutic target of psoriasis.