CD30阴性淋巴瘤样丘疹病2例及文献复习

Two Cases of CD30-Negative Lymphomatoid Papulosis and Literature Review

目的探讨中国人淋巴瘤样丘疹病的临床特点。方法对本院确诊的2例CD30阴性淋巴瘤样丘疹病患者的临床表型进行详细报告,并将结果与自1993年以来国内发表的35例中国人淋巴瘤样丘疹病患者临床资料进行综合对比分析,总结中国人淋巴瘤样丘疹病的临床特点。结果 37例患者中,男23例,女14例;发病年龄9~80岁,平均(42.44±16.51)岁;发病到就诊平均时间为(64.91±96.76)个月,多中年发病,病程呈慢性经过。病因不详,无明显相关的伴发疾病,大部分患者无不适症状,少数患者有瘙痒,皮疹可表现为局限性和泛发性,呈现丘疹、坏死、溃疡、结痂和萎缩等多形性改变,一般不侵犯指甲、掌趾、口腔和外阴等黏膜部位;组织病理学特征为真皮浅层至深层血管周围异质性T淋巴细胞增生,病理表型多样,治疗方法多种。结论淋巴瘤样丘疹病多发生于中年人群,男性发病例数较女性多,首发皮疹多分布于躯干或四肢,可呈现为局限型或泛发型,组织病理呈谱系性改变,该病总体预后较好。

Objective To analyze the clinical features of lymphomatoid papulosis（LyP）.Methods Two cases of LyP from our hospital and 35 cases which were reported in domestic documents from 1993 to present were reviewed retrospectively.Results There were 23 males and 14 females among 37 LyP patients,the range of age onset was 9 to 80 years old,the mean age of onset was（42.44±16.51）years old.The process of this disease was chronic disease and middle aged people were more prone to this disease.Major patients had no symptoms,a small number of patients with itching.The rash can be expressed as limitations or generalized and generally did not involve the nail,palm,mouth,vulva and other mucosal parts.Histopathological features of LyP was the T lymphocyte infiltration from superficial dermis to deep vascular around and pathological phenotype was diversity,various therapies have been reported to be used to treat LyP.Conclusion There were significant differences between males and females in incidence rate,the first skin eruption mainly located in trunk or limbs and can be expressed as limitations or generalized,histopathology features of LyP showed the spectrum change,the overall survival of the patient was well.