CXCL1在食管胃交界处腺癌中的表达及与患者预后的关系

Expression of CXCL1 in Adenocarcinoma of Esophagogastric Junction and Its Relationship with Prognosis

目的检测趋化因子1(CXCL1)在食管胃交界部腺癌中的表达,探讨其在癌症预后评价中的作用。方法采用免疫组织化学的方法,检测2010年至2012年被河南省肿瘤医院确诊为食管胃交界部腺癌且有组织蜡块的121例癌症患者组织中CXCL1的表达,并经随访统计各位患者生存期情况。用χ2检验的方法比较CXCL1的表达差异,用Kaplan Meier法分析其生存情况,并用Log rank test比较,预后分析采用多因素Cox回归。结果 92例(76.03%)为CXCL1阳性表达,29例(23.97%)为阴性表达,且CXCL1的表达在高中分化、III或IV期及有淋巴结转移的患者中,均显著增高。CXCL1表达阳性的患者,无病生存期及总生存期较表达阴性的患者显著缩短,且经Cox多因素分析,CXCL1的表达、癌症分化程度、分期、淋巴结的转移都是影响无病存活期与总生存期的重要因素。结论 CXCL1可能与食管胃交界处腺癌的发生、发展及预后有关,或可作食管胃交界部腺癌判断预后及治疗的一个新的分子靶点。

Objective To investigate the expression of chemokine （ C-X-C motif） ligand 1 （ CXCL1 ） in adenocarcinoma of the esophagogastric junction （AEJ） and to explore its role in the prognosis of AEJ. Methods Immunohistochemical method was used to detect the expression levels of CXCL1 in 121 cases of patients from 2010 to 2012 who were diagnosed as AEJ by Henan tumor in the hospital. The survival period of the patients was also followed- up. The expression of CXCL1 was compared by X2 test. The survival was analyzed by Kaplan Meier method, and compared by Log rank test. The prognosis was analyzed by multivariate Cox regression. Results 92 cases （76. 03% ）were positive for CXCL1 expression, 29 cases （23.97%） were negative expression, and the expression of CXCL1 was significantly higher in patients with high grade differentiation, stage III or IV and lymph node metastasis. CXCL1 expression positive patients had significantly shorterdisease-free survival and total survival compared with patients who had negative expression. Through Cox multivariate analysis, CXCL1 expression, cancer differentiation, staging, lymph node metastasis are important factors that can affect patients＇ disease-free survival and total survival. Conclusion CXCL1 may be related to the occurrence, development and prognosis of AEJ, and may be a new molecular target for the prognosis and treatment of AEJ.