PCT、sTREM-1及病原体联合检测在呼吸道感染诊断中的应用价值研究

Study on Application Value of Combined Detection of PCT,sTREM-1 and Pathogen in Diagnostic Process of Respiratory Infection

目的研究PCT、s TREM-1及病原体联合检测在呼吸道感染诊断中的应用价值。方法在2015年1月至2016年12月期间,我院共收治呼吸道感染患者85例,其中细菌感染患者42例(细菌感染组),非细菌感染患者43例(非细菌感染组),然后以同期在我院行健康体检的45例健康人群作为对照组。定量检测上述受试者血清PCT、s TREM-1水平,并分析其病原体阳性情况,最后对上述数据进行统计学分析。结果细菌感染组患者血清PCT、s TREM-1水平及病原体阳性率均显著高于非细菌感染组和对照组(P<0.05);相比较治疗前,治疗后细菌感染组患者血清PCT、s TREM-1水平及病原体阳性率明显降低(P<0.05);相比较单独检测,联合检测PCT、s TREM-1、病原体阳性率灵敏度和特异性最高(P<0.05),且其ROC曲线面积最大。结论 PCT、s TREM-1及病原体联合检测能准确诊断呼吸道感染,具有重要的临床价值。

Objective To study the application value of combined detection of PCT, sTREM- 1 and pathogen in diagnostic process of respiratory infection. Methods From January 2015 to December 2017,85 patients with respiratory infection treated in our hospital were enrolled as cases, including 42 cases of patients with bacterial infection（ infection group ） and 43 patients with non-bacterial infection （ non-bacterial infection group ）. 45 healthy people for health examination in our hospital were considered as the control group in the same period of time. The levels of PCT and sTREM-1 in serum were detected quantitatively, with the positive of the pathogen analyzed, and the data were statistically analyzed. Results The level of PCT, sTREM- 1 in serum and the pathogen positive rate in bacterial infection group were significantly higher than the non-bacterial infection group and the control group （ P 〈 0.05 ） ; Compared with before treatment, the level of PCT, sTREM- 1 in serum and the pathogen positive rate in bacterial infection group were significantly lower than after treatment （P 〈 0. 05 ） ; Compared with single detections, the sensitivity and specificity was highest by combining detection of PCT, sTREM- 1 and so was the positive rate of pathogens （ P 〈 0.05 ）, also with the largest area of the ROC curve. Conclusion We can diagnose respiratory infection accurately by combined detection of PCT, sTREM-1 and pathogen, which has the important clinical values.