清肺通络合剂对肺炎支原体肺炎儿童T细胞亚群的影响

Effect of Qingfei Tongluo mixture on T lymphocyte subpopulation in children with mycoplasma pneumoniae pneumonia

目的:研究清肺通络合剂对肺炎支原体肺炎的疗效及其对T细胞亚群的影响。方法:60例病例随机分为治疗组和对照组,每组30例。对照组采用阿奇霉素静点,治疗组在对照组基础上加清肺通络合剂,比较治疗前后证候积分及T细胞亚群的变化。结果:治疗后治疗组症状(如发热、咳嗽、痰壅便干、尿黄等)持续时间与对照组比较,差异有统计学意义(P<0.05);治疗后治疗组在证候积分上与对照组相比,差异有统计学意义(P<0.05);治疗后治疗组CD8^+、CD4^+/CD8^+值较治疗前明显改善(P<0.05),且与对照组比较,差异有统计学意义(P<0.05)。结论:清肺通络合剂治疗小儿支原体肺炎临床疗效肯定,能在一定程度上调节免疫状态,值得进一步研究并逐步推广。

Objective：To study the clinical efficacy and changes of T lymphocyte subsets of Qingfei Tongluo mixture in children with Mycoplasma pneumoniae pneumonia （pneumonia cough disease and syndrome of phlegm heat in the lung）. Method：60 hospitalized children with the inclusion criteria from April 2015 to October 2016 in Tianjin Nankai hospital were randomly divided into treatment group and control group with 30 cases in each group. The control group was treated with azithromycin intravenous treatment,while the treatment group were treated with oral Qingfei Tongluo mixture and azithromycin intravenous therapy. The changes of the score of the syndromes and the T lymphocyte subpopulation before and after treatment were observed. Results ：The treatment group was superior to the control group in alleviating the symptom and shortening the length of hospital stay.The difference of CD8＋,CD4＋/CD8＋ in the treatment group before and after treatment was statistically significant. There was significant difference between the two groups in the difference of CD8＋, CD8＋＋/CD8＋＋ after treatment. Conclusion ：The clinical efficacy of Qingfei Tongluo mixture for children with mycoplasma nneumonia is certain, which is worth further study and gradually promote.