SUMO化修饰在肺部疾病中的作用

Roles of SUMO modification in pulmonary diseases

小泛素（smallubiquitin-related modifier，SUMO）是一种结构上与泛索相似的分子，作为一种重要的翻译后修饰，SUMO化修饰对蛋白质功能有广泛调节作用，包括调节蛋白间相互作用、蛋白转录活性、DNA损伤修复、基因稳定性调节及生物节律等。近年来，SUMO化修饰在肺脏中的作用逐渐被发现，SUMO通过与靶蛋白结合作用于肺，并与肺生物学功能和肺脏疾病有所关联。

Small ubiquifin-related modifier（SUMO） is a small molecule that is structurally similar to ubiquitin. SUMOylation has emerged as an important post-translational modification. It profoundly influences the function of proteins, including the regulation of protein-protein interaction, the activity of protein transcription, DNA damage repair, gene regulation and biological rhythm. In recent years, evidence suggests that the SUMOyla- tion plays crucial roles in lung. By binding to target proteins, SUMO is associated with pulmonary biological function and disease.