雾化吸入硫酸镁治疗儿童哮喘的研究进展

Advances in the role of inhaled magnesium sulphate in childhood asthma

硫酸镁已经被证实为一种儿童哮喘的补充治疗药物，其可能作用机制主要有抑制钙离子内流人呼吸肌、减少神经肌接头处神经递质释放、减少神经终板乙酰胆碱的去极化等。多个临床随机对照试验结果表明雾化吸入硫酸镁不仅可改善哮喘患儿的肺功能等指标，而且具有安全性及有效性。随着硫酸镁在成人，尤其是成人急性重度哮喘中的应用，其在儿童哮喘中的作用机制、给药剂量、安全性、有效性等方面已愈加被重视。

Magnesium sulfate is a supplementary therapy strategy in pediatric asthma, its mechanisms in- cludes inhibiting calcium ion from inflowing into respiratory muscle, reducing the release of the in nerve-muscle junction and the depolarization of acetylcholine in the motor endplates, etc. Nebulised magnesi- um sulfate not only can improve the pulmonary function of the children with asthma, but also be safe and effe- tive. With the application of magnesium sulfate in adults, especially acute severe ones, its mechanisms, dosage, safety and efficiency of magnesium sulfate in pediatric asthma draw more attention.