血清CA125联合孕酮预测早期先兆流产预后的效果分析

Clinical Study of Serum Progesterone Combined with CA125 in Predicting the Prognosis of Early Threatened Abortion

目的探究血清CA125联合孕酮检测预测对早期先兆流产预后的临床价值。方法收集妇产科门诊于2013年1月-2014年6月诊治早期妊娠的120例孕妇,其中包括80例早期妊娠先兆流产孕妇,40例早期正常妊娠孕妇;跟踪随访至孕28周,依据妊娠结局分为早期妊娠正常组40例(对照组)、先兆流产保胎成功组54例(良好组)、先兆流产保胎失败组26例(不良组);于治疗前及治疗后1、2、3周检测CA125、孕酮(P),比较两个指标单独及联合评估早期妊娠先兆流产结局的准确度、特异度及灵敏度。结果血清孕酮水平<14.84 ng/mL预测先兆流产结局的灵敏度、特异度及准确率分别为85.2%(46/54)、80.8%(21/26)、83.75%(67/80);血清CA125>52.20 ng/mL,预测先兆流产结局的灵敏度、特异度及准确率分别为88.9%(48/54)、84.6%(22/26)、87.5%(70/80);以同时满足血清孕酮<14.84 ng/mL和CA125>52.2 U/mL的综合指标为依据,预测先兆流产结局的灵敏度、特异度及准确率分别为83.3%(45/54)、96.2%(25/26)、90%(73/80)。结论综合血清孕酮及CA125量两组指标对先兆流产结局的特异度及准确度比单一指标检测有较大的提升,研究为临床评估早期先兆流产结局提供实践和理论依据。

Objective To investigate the predictive value of serum progesterone and CA125 d in the assessment of the prognosis of threatened abortion. Methods From January 2013 to June 2014 in our hospital obstetrics and gynecology clinic diagnosed as early pregnancy and 120 cases of pregnant women,including pregnant women,80 cases of threatened abortion in early pregnancy,40 cases of early normal pregnancy; followed up to 28 weeks of pregnancy,according to pregnancy outcome in early pregnancy is divided into normal group（ control group）,40 cases of threatened miscarriage abortion group 54 cases（ Group）,26 cases of threatened abortion Baotai failure group（ experimental group）; before and after treatment in 1,2 and 3 weeks CA125,progesterone（ P）,two sensitivity and early pregnancy outcome of threatened abortion alone and in combination with the evaluation index specificity and accuracy. Results The results of the sensitivity,the serum progesterone levels in predicting the outcome of threatened abortion 14. 84 ng/ml sensitivity,specificity and accuracy were 85. 2%（ 46/54）,80. 8%（ 21/26）,83. 75%（ 67/80） serum CA125 52. 20 ng/ml; predicting the outcome of threatened abortion,the sensitivity,specificity and accuracy were 88. 9%（ 48/54）,84. 6%（ 22/26）,87. 5%（ 70/80）; and at the same time to meet the comprehensive index of serum progesterone〈 14. 84 ng/mL and CA125 〉52. 2 U/mL basis predicting the outcome of threatened abortion of the sensitivity,specificity and accuracy were83. 3%（ 45/54）,96. 2%（ 25/26）,90%（ 73/80）. Conclusions The combination of progesterone and CA125 in three groups can improve the specificity and accuracy of threatened abortion. This study provides a theoretical and practical basis for clinical evaluation of Early Threatened Abortion.