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神经节苷脂联合神经生长因子治疗小儿脑损伤的治疗效果 被引量:2

The Therapeutic Effect of Ganglioside Combined with Nerve Growth Factor in the Treatment of Brain Injury in Children
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摘要 目的试分析神经节苷脂联合神经生长因子治疗小儿脑损伤的治疗效果,为临床治疗提供参考依据。方法研究将选取2016年1月-2016年12月就诊的脑损伤儿童患者60例,按照随机分组方式,分为对照组与观察组,每组平均30人。其中对照组采用的常规的治疗方法,而对照组采用的是神经节苷脂联合神经生长因子治疗方式,通过对两组小儿的临床症状恢复时间进行对比,例如神经反射、肌肉张力等作为临床观察的主要要素,以及对于患者在治疗不同阶段的神经反应意识作为对比,进行临床数据统计,得出相应的结果。结果在采取两种不同治疗方式后,幼儿患者在采用神经节苷脂联合神经生长因子治疗方式中,患者临床症状的恢复时间比常规治疗恢复时间平均少2.5±1.5天。根据幼儿神经评价标准记录,观察组患儿的神经反应意识在3-5天内有明显的效果,而对照组患儿神经意识在5-7后才开始有所反应,针对以上数据进行分析,得出临床结论。结论从两组不同治疗方式的治疗结果进行比较,神经节苷脂联合神经生长因子治疗小儿脑损伤的治疗效果更为明显。 Objective To analyze the effect of ganglioside combined with nerve growth factor in the treatment of brain injury in children and provide a reference for clinical treatment. Methods Sixty children with brain injury from January2016 to December 2016 in our hospital were selected and randomly divided into control group and observation group,with an average of 30 in each group. The control group adopted the conventional treatment,while the control group was treated with ganglioside combined with nerve growth factor therapy,by comparing the two groups of children's clinical symptoms recovery time,such as reflex,muscle tension as a clinical observation Of the main factors,as well as for patients in different stages of treatment of neural response to consciousness as a comparison,the clinical data statistics,the corresponding results were obtained: After taking two different treatment methods,the use of ganglioside in children with neurotrophic growth Factor therapy,the recovery time of patients with clinical symptoms than the average recovery time of less than 2. 5 ± 1. 5 days. According to children's neurological evaluation criteria record,observation group children's neurological reaction awareness in 3-5 days have a significant effect,while the control group of children with neurological consciousness began to react after 5-7,for the above data analysis,was Out of clinical conclusions. Conclusions The treatment effect of ganglioside combined with nerve growth factor in children with brain injury is more obvious than that of two different treatment methods.
作者 高玉琼 GAO Yuqiong(Central Hospital of Zhengzhou ,Henan)
出处 《航空航天医学杂志》 2018年第2期143-144,共2页 Journal of Aerospace medicine
关键词 神经节苷脂 神经生长因子 小儿脑损伤 治疗效果 ganglioside nerve growth factor with brain injury in childre the therapeutic effect
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  • 1Kawakami N,Kashiwagi S,Kitahara T, et al. Effect of local abmin- stration of basic fibroblast growth factor against neuronal damage caused by transient intracerebral mass lesion in rats[ J]. Brain Res, 1995,697 : 104.
  • 2Komacka MK. Magnesium sulphate in the treatment of ischemic-hy- poxic neonatal encephalopathy [ J ]. Neurol Neuroehir Pol,2001,35 ( 2 ) : 299 - 308.
  • 3Alfred LS. Management and treatment planning for the abnormally developing child[ M]//Alfred LS. Early diagnosis and intervention- al therapy in cerelbral palsy. 3ed. New York: Marcel Dekker Inc, 2001:95 - 119.
  • 4Michal AE,Amy GB,Kelsey B. Intrauterine inflammation,insufficient to induce parturition,still evokes fetal and neonatal brain injury[J].{H}International Journal of Developmental Neuroscience,2011,(6):663-671.
  • 5Van Velthoven CT,Kavelaars A,Van Bel F. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration[J].Brain Behavior Immun,2010,(3):387-393.
  • 6Julie AW,Hanna ER,Kathryn MB. Evidence that the serotonin transporter does not shift into the cytosol of remaining neurons after neonatal brain injury[J].{H}Neuroscience Research,2012,(3):252-256.
  • 7Tatyana V,Ali F,Michael VJ. Pluripotent possibilities:human umbilical cord blood cell treatment after neonatal brain injury[J].{H}PEDIATRIC NEUROLOGY,2013,(5):346-354.
  • 8Umral K,Tuzun F,Tuqyan K. Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury[J].{H}EARLY HUMAN DEVELOPMENT,2013,(3):165-173.
  • 9Irina B,Kirstin L,Michael M. 45:Inflammation-induced preterm birth (Ⅱ-PTB):prenatal ILl β blockade prevents neonatal brain injury in a region specific manner but not preterm birth[J].{H}AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY,2012,(1):30-31.
  • 10赵继宗主编.神经外科学[M]. 人民卫生出版社, 2007

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