小泛素样修饰蛋白1和P53的表达与子宫平滑肌肉瘤发生的相关性研究

Expression and clinical significance of small ubiquitin-like modifier-1 and P53 protein in uterine leiomyosarcoma

目的了解小泛素样修饰蛋白(SUMO)-1、P53蛋白在子宫平滑肌肉瘤中的表达及其临床意义。方法收集2006年3月—2012年3月期间接受手术治疗的20例子宫平滑肌肉瘤,29例良性子宫平滑肌瘤,采用免疫组织化学Envision法检测各组织中SUMO-1和P53蛋白的表达,对收集的20例子宫平滑肌肉瘤患者进行电话随访预后情况。结果 SUMO-1、P53在子宫平滑肌肉瘤组中阳性表达率分别为85%、30%;在子宫平滑肌瘤组中阳性表达率分别为52%和0%;子宫平滑肌肉瘤组中的SUMO-1阳性表达率明显高于子宫平滑肌瘤组(P<0.01);子宫平滑肌肉瘤组中的P53阳性表达率明显高于子宫平滑肌瘤组(P<0.01);子宫平滑肌肉瘤中SUMO-1与P53蛋白表达无明显相关性;SUMO-1、P53蛋白的表达分别与子宫平滑肌肉瘤预后均无相关性(P>0.05)。结论 P53可能与子宫平滑肌肉瘤的发生机制相关,并对子宫平滑肌肉瘤与子宫平滑肌瘤有一定的鉴别诊断价值;SUMO-1可能与子宫平滑肌肉瘤的发生密切相关。

Objective To learn the expression and significance of small ubiquitin-like modifier（SUMO）-1 and P53 protein in uterine leiomyosarcoma. Methods From March 2006 to March 2012, 20 cases of uterine leiomyosarcoma and 29 cases of uterine leiomyoma were collected. Immunohistochemical Envision method was used to detecte the expression level of SUMO-1 and P53 in 49 cases with uterine sarcoma, and prognosis was followed up by telephone in 20 cases of uterine leiomyosarcoma. Results The positive expression rates of SUMO-1 and P53 in uterine leiomyosarcoma were 85% and 30%, respectively; the positive expression rates of SUMO-1 and P53 in uterine leiomyoma were 52% and 0%, respectively; the positive expression rate of SUMO-1 in uterine leiomyosarcoma was significantly higher than that in uterine leiomyoma（P0.01）; the positive expression rate of P53 in uterine leiomyosarcoma was significantly higher than that in uterine leiomyoma（P0.01）; the expressions of SUMO-1 and P53 protein in uterine leiomyosarcoma were not associated with prognosis（P0.05）. Conclusion P53 may be implicated in the pathogenesis of uterine leiomyosarcoma and is useful in differentiating uterine leiomyosarcoma from uterine leiomyoma. SUMO-1 could be closely related to the occurrence of uterine leiomyosarcoma.