益生菌临床应用的研究进展

Research progress of probiotics in clinical application

近年来,研究发现多种疾病的发生与肠道菌群失调密切相关,而益生菌在维持肠道菌群平衡中起重要作用。益生菌在预防和治疗腹泻、肥胖、肝脏损伤、肿瘤等疾病中展示良好的效果,其临床制剂的开发已成为当前研究的热点。随着益生菌制剂的广泛使用,益生菌可能带来的不良反应也需要得到重视。本文阐述了益生菌制剂对疾病的预防、治疗及不良反应的研究进展,旨在为益生菌精准治疗及拓展益生菌临床应用提供理论依据。

Probioties play an important role in maintaining the balance of intestinal flora. More and more studies have found that the occurrence of multiple diseases is closely related to intestinal flora imbalance. Therefore, the development of probiotics clinical agents has become the focus of current research. The studies have found that probiotics have good effects in the treatment and prevention of diarrhea, obesity, liver injury, cancers and other diseases. With the widespread use of probiotics clinical agents, the adverse effects of probiotics should be paid attention. Advances of probiotics in the prevention, treatment of diseases and its adverse reactions are described in this paper in order to provide a theoretical basis for the accurate treatment and expanding the clinical application of probiotics.