探讨抗生素降阶梯疗法对重症肺炎患儿的临床疗效评价

Clinical curative effect evaluation of antibiotic de-escalation therapy on children with severe pneumonia

目的探讨抗生素降阶梯疗法对重症肺炎患儿的临床疗效评价及分析。方法选取100例重症肺炎患儿并依据治疗方法分为参照组和实验组,参照组患儿给予常规治疗方法,实验组患儿给予抗生素降阶梯治疗方法,对两组临床疗效进行评价。结果实验组患儿治疗总有效率为94%(47/50),明显高于参照组患儿的76%(38/50)(P<0.05);实验组患儿治疗满意度为94%(47/50),显著高于参照组患儿的68%(34/50)(P<0.05);实验组患儿不良反应发生率为6%(3/50),明显低于参照组患儿的20%(10/50)(P<0.05);实验组患儿死亡率为2%(1/50),显著低于参照组患儿的16%(8/50)(P<0.05);实验组患儿气管插管率为12%(6/50),明显低于参照组患儿的32%(16/50)(P<0.05);实验组患儿抗生素使用时间、住院时间均短于参照组患儿(P<0.05)。结论抗生素降阶梯治疗重症肺炎患儿的临床疗效显著,且应用价值高。

[Objective] To investigate the clinical curative effect evaluation of antibiotic de-escalation therapy on children with severe pneumonia. [Methods] Totally 100 patients with severe pneumonia were divided into two groups according to the treatment methods, namely the control group and the experimental group. The control group received routine treatment, and the experimental group was given de-escalation therapy. The clinical efficacy of the two groups was evaluated. [Results] The total efficiency and treatment satisfaction in the experimental group were significantly higher than those in the control group （P 〈0.05）; the incidence of adverse reactions, the intubation rate and mortality in the experimental group were significantly lower than those in the control group （P 〈0.05）; antibiotic use time, hospitalization time in the experimental group were shorter than those in the control group （P 〈0.05）. [Conclusion] Antibiotic de-escalation therapy in children with severe pneumonia has high clinical application value.