福尔马林储骨的移植实验

The Transplantion Experiment with Bone Allografts Preserved in Formalin

用家兔14只，以桡骨中段10mm骨缺损作为实验模型，右侧植入同种异体福尔马林储骨为实验组，左侧植入酒精储骨作为对照组。于术后2、4、8、10、12周取材，作X线片和普通光镜观察，结果显示：福尔马林储骨移植术后4周缺损区有大量新骨形成，骨质增生活跃。8周时移植骨大部分被新生骨替代。12周时骨缺损基本愈合。结果表明，经福尔马林处理后的同种异体骨有较好的生物相容性，能引导骨生长，从而为推广尸体骨移植的临床应用，简化骨处理步骤提供了实验依据。

Defects of 10 mm in length on the metaphyses of bilateral radii in 14 rabbits were made by dental drill as this experimental models. Bone allografts preserved in formalin were transplanted into the defects on the right side of radius,and bone allografts preserved in alcohol were simultaneously transplanted into the defects on the left side of radius as control. By two, four,eight,ten and twelve weeks after operation,specimens from these rabbits were collected and observed by radiography and ordinary microscopy. The results showed new bone formation and hyperosteogny in the defects. The transplanted bones were replaced largely by the new bone at eight weeks. The defects were almost stuffed up at twelve weeks. It is suggested that formalin preserved bone grafts have good biocompatibility and are able to conduct the progressive growth of the bone. Therefore, these results offer an experimental basis for popularizing clinical application of transp1antion with cadaver bone and simplifying its procedure.