表皮生长因子受体在口腔鳞癌组织中的表达及意义

The Expression and Significante of EGFR in the Tissues of Oral Squamous Cancer

为了解口腔鳞状细胞癌中表皮生长因子受体（EGFR）的表达、临床特征、细胞分化及生物学行为的关系，本文采用免疫组化方法检测了50例口腔鳞癌和12例癌旁正常组织的石蜡标本．发现癌组织中28例出现表皮生长因子受体（EGFR）阳性表达，表达率为56％，而在癌旁正常组织中则无1例出现EGFR阳性表达，EGFR阳性表达与患者的年龄、肿瘤部位和颈部淋巴结转移无相关性（P＞0．05）；而与病理分级和TNM分期以及仲瘤复发有明显的相关性（P＜0．05）．同时发现吸烟患者肿瘤中EGFR为高度表达；浸润性肿瘤中EGFR的阳性表达率明显高于非浸润性肿瘤（P＜0．05）．提示EGFR能很好地反映口腔鳞癌的增殖活性，其高度表达可作为评价病人预后较差的参数之一，在临床病理上具有应用前景。

To investigate the relationship between the expression of EGFR(epidermal growth factor receptors)in the tissues of oral squamous cancer and clinical features,cellular division and biological behavior,paraffin embeded specimens from 50 cases oral squamous cancer and 12 normal specimens adjacant to cancerous tissue were studied immunohistochemically.A positive rate of 56% (28 in 50 cancerous specimens)was found,but none in normal specimens. The positive expression was not related with patients’ age, location of tumor and metastatic lymph nodes in neck (P>0. 05) ; but with pathological grade, TNM stage and tumor recurrence (P<0.05)significantly. It was also found that EGFR had a strong expression among smoking patients. The rate of positive expression in invasive cancers. Was significantly higher than that in noninvasive cancers. The results suggest that EGFR renect the proliferation activity of oral squamous cancer. A strong expression could be used as one of the parameters indicating a poor prognosis. There is applicable prospect in clinical pathology.