乙型肝炎重叠感染的临床研究

Clinical Study of Superinfection by Hepatitis Viruses in Hepatitis B

对128例乙型肝炎重叠感染甲、丙、丁、戌型肝炎病毒的临床经过及预后与单纯乙肝病毒感染进行了分析对比。结果表明HBV重叠HAV感染大多呈急性经过，预后痕好。HBV与HCV、HDV、HEV重叠感染后，重症肝炎的发生率及病死率明显增高，依次为己戌、乙丙、乙丁重叠感染．原有肝脏的损害程度与病死率呈正向关系。重叠感染后部分患者的乙肝病毒复制受到抑制并可能被清除．

Comparing with hepatitis B patients without any other hepatitis virus infection, one hundred and twenty eight cases of hepatitis B with super infection of hepatitis A virus (HAV),hepatitis C virus (HCV),hepatitis D virus (HDV) and hepatitis E virus (HEV)were analysed for their clinica course and prognosis. The results indicated that most of hepatitis B with superinfection of HAV had an acute course and good prognosis,but the incidence and the mortality of fulminant hepatitis in hepatitis B patients with superinfection of HCV,HDV,and HEV were much higher than those in hepatitis B patients witbout any other hepatits virus infection,being HEV,HCV and HDV respectively.The degree of previously hepatic damage was directly related with the mortality of these patients. After superinfection with HAV、HCV,HDV and HEV,the replication of HBV was inhibited and HBV mght be eliminated in part of hepatitis B patients.