肾癌增殖细胞核抗原的研究

Proliferating Cell Nuclear Antigen(Pc10) in Renal Cancer

为探讨肾癌的生物学行为及预后，采用免疫组化ＡＢＣ法对５３例肾癌组织中ＰＣＮＡ进行检测，取６例肾错构瘤及正常肾组织作为对照。结果发现：肾错构瘤中未见ＰＣＮＡ着色，在正常肾组织中仅见少许细胞着色，而肾癌所有切片均呈阳性反应。肾癌组织的ＰＣＮＡ表达与肿瘤分期、分级均相关，ＰＣＮＡ高表达组（３～４级）术后５年生存率显著较ＰＣＮＡ低表达组（１～２级）短。ＰＣＮＡ可定量地判断肿瘤分化程度及恶性度。

Proliferating cell nuclear antigen (PCNA) was arrayed by immunohistochemical methods in 53 cases of renal cancer,using 6 cases of renal angiomyolipoma and normal renal tissue for control.The results were as follows:No positive immunostaining cell was found in renal angiomyolipoma,a few cells in normal renal tissue were stained,and PCNA was expressed in all renal cancer specimens.PCNA expression correlates with staging and grading of the tumor.The survival rate of higher PCNA expression (3￣4 grade) was lower than that of lower expression (1￣2 grade).PCNA can judge the degree of differentiation and malignancy of neoplasms quantitively and may act as an independent criterion for the prognosis of renal cancer.