奥美拉唑与法莫替丁抗消化性溃疡的临床评价

Clinical Evaluation of Omeprazole and Famotidine in Treating Peptic Ulcer

为了观察消化性溃疡患者分别应用奥美拉唑（Ｏｍｅｐｒａｚｏｌｅ，Ｏｍｅ）和法莫替丁（Ｆａｍｏ－ｔｉｄｉｎｅ，Ｆａｍ）治疗后的疗效和不良反应。对１６０例经确诊的消化性溃疡患者随机分为２组，Ｏｍｅ组（男性６１例，女性１１例，年龄４５．１±１４．３岁），每天口服Ｏｍｅ２０ｍｇ，早餐后顿服。Ｆａｍ组（男性７２例，女性８例，年龄４３．７±１１．２岁）每天口服Ｆａｍ两次，每次１０ｍｇ。结果：Ｏｍｅ组溃疡４周愈合率９５．０％，明显高于Ｆａｍ组８３．７５％（Ｐ＜０．０５），２周愈合率８２．５％，明显高于Ｆａｍ组６５．０％（Ｐ＜０．０５）。服药１～３ｄ的疼痛消失率６８．６％，远高于Ｆａｍ组的５２．２％（Ｐ＜０．０５）。可见Ｏｍｅ在抗消化性溃疡方面有溃疡愈合快、愈合率高及缓解症状迅速的优点。在治疗过程中Ｏｍｅ组出现了多种不良反应，发生率１８．７５％，高于Ｆａｍ组（Ｐ＜０．０１），但出现的不良反应继续用药可自行减轻至消失。结论：Ｏｍｅ是目前治疗消化性溃疡的较安全有效的药物之一。

AIM:To observe the clinical effects of Omeprazole and Famotidine on peptic ulcer METHODS:160 patients with peptic ulcer were randomly divided into 2 groups ,treated with Omeprazole or Famotidine respectively. The Omeprazole group received Omeprazole 20mg;PO.,qd.The Famotidine group received Famotidine 10mg;PO.Bid.RESULTS:4 week cure rate of Ome group 95 0%, that of Fam group 83 75%; 2 week cure rate of Ome group 82 5%,that of Fam group 65 0%; 1～3 d analgesia rate of Ome group 68 6%, that of Fam group 52.2%; indicating significant differences between the 2 groups ( P <0 05) in cure rate, time reguired for cure are analgesia.A few of adverse reactions appeared in the Ome group(18.75%) and less in the Fam group ( P<0 01) , but the adverse reactions disappeared spontaneously.CONCLUSION:Omeprazole is a comparatively safer and more effective drug in treating peptic ulcer.