肝脏不同类型细胞衰老对肝纤维化发生发展的影响

Influence of different types of cell senescence on the development and progression of liver fibrosis

细胞衰老是细胞在受到某些特定刺激后而被激活的一种基本细胞应答程序,是生物机体的基本特征。肝纤维化是由各种致病因子所致肝内结缔组织异常增生,导致肝内弥漫性细胞外基质过度沉积的病理过程,可发展为肝硬化、肝癌。研究表明细胞衰老与肝纤维化的进展密切相关,针对肝内各种类型细胞衰老对肝纤维化的调控作用进行了综述。

Cell senescence is a basic cell response triggered by various stimuli and is a basic characteristic of living organism. Liver fibrosis refers to the pathological process of diffuse excessive deposition of extracellular matrix in the liver caused by abnormal proliferation of connective tissue due to various pathogenic factors and can progress to liver cirrhosis and liver cancer. Studies have shown that cell senescence is closely associated with the progression of liver fibrosis. This article reviews the regulatory effect of different types of cell senescence on liver fibrosis.