细胞外囊泡与肝脏疾病发生发展的关系

Role of extracellular vesicles in the development and progression of liver diseases

细胞外囊泡(EV)是细胞释放到细胞外环境中的膜结合小泡,能够选择性地富集特定蛋白和RNA,介导细胞间通讯。因此,EV具有作为疾病的生物标志物、治疗靶标和传递载体的潜力。总结了EV在病毒性肝炎、肝纤维化和肝癌中的研究进展,探讨其在肝脏疾病中所发挥的作用,以强调EV在未来肝脏疾病研究中的应用前景。

Extracellular vesicles（ EVs） are membrane-bound vesicles released by cells into the extracellular environment and can selectively enrich specific proteins and RNA and mediate intercellular communication. Therefore,EVs have the potential of a biomarker for diseases,a therapeutic target,and a delivery vector. This article reviews the research advances in the role of EVs in viral hepatitis,liver fibrosis,and liver cancer and emphasizes the prospects of EVs in liver diseases.