稳定期重症肌无力患者的睡眠质量及其影响因素的研究

Study of sleep quality and influence factors in patients with stable myasthenia gravis

目的探讨稳定期重症肌无力(MG)患者睡眠质量及影响因素。方法采用匹兹堡睡眠质量指数(PSQI)评价2015年9月至2017年2月四川大学华西医院神经内科门诊收治的151例稳定期MG患者的睡眠质量,Spearman相关分析影响因素(临床资料、生活质量、焦虑、抑郁)。结果 Spearman分析示患者年龄、病程、重症肌无力生存质量量表(MG-QOL15)、汉密尔顿焦虑量表(HAMA14)、汉密尔顿抑郁量表(HADA24)与PSQI总分呈正相关。行逐步线性回归发现低水平生活质量为MG患者低质量睡眠的最佳预测因子(t=3.161,P=0.002),接着是抑郁(t=2.495,P=0.014)、年龄(t=2.356,P=0.020)。结论稳定期MG患者睡眠质量的的影响因素较多,应予以重视。

Objective To investigate the sleep quality and influencing factors in patients with stable myasthenia gravis （MG）. Methods From September 2015 to February 2017, 151 cases of stable MG were enrolled in the department of neurology, West China Hospital, Pittsburgh sleep quality index （PSQI） was used to evaluate their sleep quality; Spearman analysis was used to analyze the influencing factors （clinical data, quality of life, anxiety and depression）. Results Spearman test analysis showed that PSQI was positively correlated with age, duration, myasthenia gravis quality of life 15 （MG-QOL15）, Hamilton Anxiety Scale 14 （ HAMA14 ） , Hamilton Depression Scale 24 （ HADA24 ） （ P 〈 0.05 ）. Stepwise regression analysis further revealed that life quality was the best predictor of reduced sleep quality （ t = 3. 161, P = 0. 002）, followed by anxiety （ t = 2. 495, P = 0. 014） and age （ t = 2. 356, P = 0. 020 ）. Conclusions There are many influencing factors of stable MG wnich more attentions should be paid on .