柴胡加龙骨牡蛎汤对颞叶癫痫患者SOD、MDA的影响

Effects of Chaihu-Longgu-Muli Decoction on the levels of blood superoxide dismutase and maiondiaidehyde in Temporal Lobe Epilepsy patients

目的探讨柴胡加龙骨牡蛎汤(CLMD)对颞叶癫痫患者超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。方法将65例颞叶癫痫患者,按完全随机表法分成奥卡西平组(32例)、奥卡西平+CLMD组(33例),治疗28 d后,观察两组临床疗效、血清中SOD、MDA变化及不良反应。结果奥卡西平+CLMD组临床总有效率为87.8%,显著高于奥卡西平组53.1%,差异有统计学意义(P<0.05);两组治疗后SOD升高、MDA降低,与治疗前比较差异有统计学意义(P<0.05或P<0.01),且奥卡西平+CLMD组较奥卡西平组SOD升高、MDA降低(P<0.05或P<0.01);两组不良反应比较差异无统计学意义(P>0.05)。结论 CLMD对颞叶癫痫患者有明确治疗作用,安全性高,其机制可能与其增加SOD,降低MDA,抗氧化应激有关。

Objective To investigate the effects of Chaihu-Longgu-Muli Decoction （CLMD） on superoxide dismutase （SOD） and maiondiaidehyde （MDA） in patients with temporal lobe epilepsy （TLE）. Methods 65 patients with TLE were randomly divided into Oxearbazepine group （n = 32 ） and Oxcarbazepine ＋ CLMD group （n = 33）. After 28 d, the curative effect, SOD, MDA changes in serum and side effect were observed between two groups. Results The clinical effective rate in Oxearbazepine ＋ CLMD group was 87.8% , slightly higher than that of the Oxcarbazepine group（53.1% ） （P 〈0. 05）. After treatment, serum SOD was significantly higher in the patients than before treatment in two groups, but serum MDA was significantly lower（ P 〈 0. 05 or P 〈 0. 01 ） , while the above changes were more obvious in the Oxcarbazepine ＋ CLMD group （P 〈 0. 05 ）. No statistically significant differences of side effect （ P 〉 0. 05 ）. Conclusions CLMD has higher curative effect with less side effect,which can lead to increase of the level of SOD and decrease of the level of MDA, and the mechanism is related to oxidative stress.