血浆神经递质浓度与产后抑郁症的关系（英文）

Plasma concentrations of neurotransmitters and postpartum depression

目的:探讨血浆神经递质与产后抑郁症(postpartum depression,PPD)的关联。方法:于2007年2至9月在湖南长沙3家三甲医院开展一项前瞻性巢式病例对照研究。运用爱丁堡产后抑郁量表(Edinburgh Postnatal Depression Scale,EPDS)中文版对产后2周产妇进行PPD筛查,得分≥13分者确定为PPD患者(n=42)。每个PPD患者按1:1抽取正常产妇为对照组(n=42),两组按照分娩医院(同一医院)与年龄(±5岁)进行匹配。在产后2周抽取血液样本,比较PPD组和对照组产妇的血浆单胺类递质及肽类神经递质水平,其中血浆单胺类递质包括5-羟色胺(5-hydroxytryptamine,5-HT)、多巴胺(dopamine,DA)、去甲肾上腺素(norepinephrine,NE),肽类神经递质包括神经肽Y(neuropeptide Y,NPY)和P物质(substance P,SP)。结果:PPD组5-HT和NPY血浆水平明显低于对照组,而NE和SP血浆水平明显高于对照组(均P﹤0.05)。PPD组NPY和NE血浆水平之间呈负相关(r=–0.36,P﹤0.05)。结论:PPD产妇存在多种神经递质水平的改变,不同神经递质之间具有潜在相互作用。

Objective： To determine associations between postpartum depression （PPD） and plasma neurotransmitters. Methods： We conducted a case-control study nested to a prospective cohort established in 3 comprehensive tertiary hospitals in Changsha, Hunan, China from February to September 2007. The Chinese version of the Edinburgh Postnatal Depression Scale （EPDS） was used at 2 weeks postpartum to screen PPD, with a score of 13 or higher as the cut-off for PPD. The women with matched age but without PPD and delivery within 5 years were selected as controls. The levels of plasma monoamine neurotransmitters including serotonin （5-hydroxytryptamine, 5-HT）, dopamine （DA）, and norepinephrine （NE）, and peptide neurotransmitters including neuropeptide Y （NPY） and substance P （SP） in maternal blood samples taken at 2 weeks postpartum were measured and compared between PPD women （n=42） and controls （n=42）. Results： Plasma levels of 5-HT and NPY were significantly lower while plasma levels of NE and SP were significantly higher in PPD women than those in the controls. For women with PPD, a negative correlation between NPY and NE （r=-0.36, P〈0.05） was observed. Conclusion： There are changes in plasma levels of neurotransmitters in women with PPD, and there are potential interactions between different neurotransmitters.