芪海消瘿汤治疗慢性淋巴细胞甲状腺炎临床研究

Clinical Study on Chronic Lymphocytic Thyroiditis (CLT) Treated by Qihai Xiaoying Decoction

目的:观察芪海消瘿汤治疗慢性淋巴细胞性甲状腺炎的临床疗效。方法:100例分为对照组45例和治疗组55例,两组均用左甲状腺素钠治疗,治疗组加用芪海消瘿汤治疗。结果:总有效率治疗组91.0%、对照组71.1%,两组比较差异有统计学意义(P<0.05)。治疗后两组T_3、T_4、FT_3、FT_4、TSH皆正常,TGAb、TPOAb降低治疗组与治疗前比较差异有统计学意义(P<0.05),与对照组治疗后比较差异有统计学意义(P<0.05)。治疗后治疗组的左甲状腺素治疗平均用量明显减少,与治疗前比较差异有统计学意义(P<0.05)。甲状腺及甲状腺结节缩小,与治疗前比较差异有统计学意义(P<0.05),与对照组治疗后比较差异有统计学意义(P<0.05)。结论:芪海消瘿汤能调节慢性淋巴细胞性甲状腺炎患者免疫功能,降低抗体滴度,减少左甲状腺素钠用量,减少慢性淋巴细胞性甲状腺炎向甲减转化,阻止甲状腺细胞的凋亡,缩小肿大的甲状腺及甲状腺结节。

Objective ： To observe the clinical therapeutic effect of Qihai Xiaoying Decoction in treatment of chronic lymphocytic thyroiditis. Method： 100 patients were divided into two groups randomly, 55 cases in study group and 45 cases in control group. Both groups were treated with levothyroxine sodium tablets and the study group were treated with Qihai Xiaoying Decoction in addition. Result： The total effective rate of the study group was 91.0% while that of the control group was 71.1%. There was significant difference between the two groups （ P〈0.05 ） .After the treatment, T3, T4, FT3, FT4 and TSH of both groups was normal and TGAb and TPOAb of both groups decreased. There was significant difference in the indexes of the study group after treatment compared with that before the treatment （ P〈0.05 ） . There was significant difference in the indexes between the study group and the control group （ P〈0.05 ） . The average dosage of levothyroxine sodium tablets of the study group after the treatment reduced significantly compared with that of the control group and compared with that of the study group before the treatment （ P〈0.05 ） . The thyroid volume and thyroid nodule decreased compared with that of the control group and compared with that of the study group before the treatment （ P〈0.05 ） . Conclusion： Qihai Xiaoying Decoction could effectively regulate immune function of chronic lymphocytic thyroiditis patients, decrease the antibody titer, reduce the dosage of levothyroxine sodium tablets and reduce the transformation from chronic lymphocytic thyroiditis to hypothyroidism,inhibit the thyroid apoptosis and reduce the intumescent the thyroid and thyroid nodule.