强直性脊柱炎与妊娠

Ankylosing spondylitis and pregnancy

强直性脊柱炎(AS)是一种慢性系统性炎性疾病,主要累及骶髂关节和脊柱附着点,以软骨关节和滑膜关节以及肌腱、韧带附着于骨的部位的纤维化和骨性强直为主要病变特点,并可伴发外周关节及关节外的表现。AS在我国患病率初步调查为0.3%左右。近年来,该病的女性患者逐渐增多,对女性患者,特别是育龄期女性在妊娠前后及妊娠过程中免疫变化,以及药物治疗等都对母亲及胎儿都有一定影响,此文将对这方面的进展情况进行综述。

Ankylosing spondylitis （AS） is a chronic inflammatory disease that encroaches sacroiliac joint and process of bone of vertebral column, with the fibrosis and osseous ankylosis of parts including spine soft tissue, peripher- al joints, attachment parts of tendons and ligaments to the bone as the main pathological features, and can be associated with peripheral joints and extra articular manifestations. The prevalence of AS in China was about 0.3%. In recent years, female patients gradually increased, female patients, especially women of childbearing age before and after pregnancy and pregnancy in the immune changes, as well as drug treatment and so on have a certain impact on the mother and the fetus. This article will review the progress on ankylosing spondylitis and pregnancy.