肠道微生态对疾病的影响及其与中药的相互作用研究进展

Advance in the effect of gut microecology on diseases and interactions between gut microecology and Chinese materia medica

人体肠道中的微生物组成复杂、种类繁多、功能强大。其与宿主共同组成的肠道微生态的平衡与否,与多种疾病密切相关。粪菌移植是当前临床上用于调节肠道微生态紊乱的新兴技术,因其治疗效果显著而受到广泛关注。中药在经过消化道时,不可避免地会与肠道微生物发生相互作用。本文从肠道微生态紊乱与相关疾病、粪菌移植对肠道微生态紊乱的调节、肠道微生物对中药活性的影响、中药对肠道微生态的调节这4个方面,对肠道微生态对疾病的影响及其与中药的相互作用的国内外最新研究状况作一综述,以期为相关研究提供参考。

Numerous microbes with complicated compositions, wide varieties and powerful functions live in human gastrointestinal tract and constitute a gut microecological system along with their host. Disorder of gut microecology is closely associated to diseases. Fecal microbiota transplantation is a burgeoning clinical technique to durably regulate gut microecology dysbiosis, and attracts widespread attention for its remarkable efficacy. It is inevitable for Chinese materia medica to interact with gut microbiota when they go through the gastrointestinal tract. This paper reviewed current advances in the effect of gut microecology on diseases and interactions between gut microecology and Chinese materia medica including correlation between gut microecology disorder and diseases, regulation on gut microecology dysbiosis by fecal microbiota transplantation, effect of gut microbes on Chinese materia medica, and adjustment of Chinese materia medica to gut microecology. We hope to provide reference for relevant research.