急性髓细胞白血病中微小RNA和核因子-κB的作用及其相互关系

Role and relationship of NF-KB and microRNAs in acute myeloid leukemia

微小RNA（MiRNA）与急性髓细胞白血病（AML）的发生有一定关系，但是其具体作用机制目前尚未完全明确。多项研究已经证实，核因子-κB与AML的发生、发展密切相关，并且成为AML治疗的重要蛋白酶体抑制靶点。在包括AML在内的多种血液系统疾病的发生、发展中，MiRNA是通过核因子-κB信号通路发挥作用。笔者拟就MiRNA与核因子-κB在AML中的作用及其相互关系进行综述。

MicroRNA （MiRNA） has a certain relationship with the occurrence of acute myeloid leukemia （AML）, but its specific mechanism is not yet completely clear. A number of studies have confirmed that the nuclear factor （NF）-κB related to the occurrence and development of AML. It has become an important proteasome inhibitory target in the treatment of AML. In the development and progression of a variety of hematological diseases including AML, MiRNA functions through the NK-κB signaling pathway. This article reviews the roles and relationship between MiRNA and NK -κB in AML.