响应面法优化普鲁兰多糖-卡拉胶软胶囊囊皮配方

Optimization of the preparation process of the prouran-carrageena-soft capsule by response surface method

选取普鲁兰多糖-卡拉胶作为胶液的主要成分,探究成分配比对囊皮的透油率,抗拉强度,断裂伸长率,凝胶强度,透光率等性能指标的影响,从而确定制备普鲁兰多糖-卡拉胶软胶囊囊皮的最佳配方。在单因素实验的基础上,通过响应面实验对普鲁兰多糖-卡拉胶软胶囊囊皮的配方进行优化,得到了最佳制备方案:卡拉胶含量1.25%(复配胶配比23.5∶2.5),果糖含量4.7%,钾离子含量0.11%,此时的抗拉强度,断裂伸长率,凝胶强度分别为(34.6875±1.6253)MPa,(50.1346%±2.6834%),(463±13)g/cm^2,实验验证所得结果与理论值基本吻合,响应面优化所得结果对生产实际和深入研究具有一定指导意义。

Selection of pullulan-polysaccharides-carrageenan as the main component of adhesive solution, the effects of composition ratio on the oil permeability, tensile strength, elongation at break, gel strength and transmittance of the capsule were investigated.In order to determine the optimum conditions for the preparation of pullulan-carrageenan soft capsule skin.On the basis of single factor experiment, optimized by response surface test formula of pullulan-carrageenan soft capsule skin, obtained the best preparation plan ： Carrageenan adhesive content of 1.25% （compound gel ratio 23.5：2.5 ） ,fructose content was 4.7% , the potassium content of 0.11%, the tensile strength, elongation at break and gel strength were（ 34.6875 ± 1.6253 ） MPa, （50.1346% ±2.6834% ）, （463 ± 13） g/cm2, respectively, the experimental results showed that the difference between the theoretical results and the theoretical values was basic coincidence, the optimization results have guiding significance for the actual production and research the response surface.