组织光声弹性成像

Photoacoustic Elastography for Biological Tissue

触诊和弹性成像是测量组织硬度、反映疾病状态的常见医学诊断方法,在现有的组织弹性成像技术中超声弹性成像已经相当成熟。光声成像利用组织吸收脉冲光产生的光声信号进行成像,兼具光学成像高选择性和纯超声成像高成像深度的优点;弹性成像是将材料的弹性信息转换成图像,一般分为诱导形变、测量形变和形成图像这几个步骤。基于光声技术的弹性探测及成像的机理和技术已有报道,回顾了当前光声弹性探测的研究成果。在此基础上,基于光声信号本身即为组织热弹性形变产生的超声波,即超声波的传输与组织的弹性特性相关,提出基于光声信号的组织弹性分析,结合光声的功能成像实现功能和弹性的多功能成像,为疾病,特别是肿瘤的诊断与治疗提供更精确的信息。

Palpation and elastography are common diagnosis methods that detect tissue hardenability and reflect pathological status. Ultrasonic elastography is one of the existing highly developed tissue elastographies. Photoacoustic imaging uses photoacoustic signals generated by tissues that absorb pulsed light for imaging, combining the advantages of optical imaging with high selectivity and pure ultrasound imaging with high imaging depth. Elastic imaging transforms the elastic information of the material into images, which is divided into several steps such as induced deformation, deformation measurement and image formation. The mechanism and technique o{ elasticity detection and imaging based on photoacoustic technology have been reported, and the research results of current photoacoustic elasticity detection are reviewed. On this basis, the photoacoustie signal itself is generated by tissue thermoelastic deformation of the ultrasound, that is, the transmission of ultrasound is related to tissue elastic properties. Photoacoustic signal analysis of tissue elasticity analysis is proposed. Which combines photoacoustic function to realize multi-function imaging of function and elasticity. The proposed method can provide more accurate information {or the diagnosis and treatment of diseases, especially tumors.