清胰汤联合早期微生态肠内营养对急性胰腺炎患者血清淀粉酶、炎性细胞因子及预后的影响

Effect of Qingyi Decoction Combined with Early Micro Ecological Enteral Nutrition on Serum Amylase,Inflammatory Cytokines and Prognosis in Patients with Acute Pancreatitis

目的：探讨清胰汤联合早期微生态肠内营养对急性胰腺炎患者血清淀粉酶、炎性细胞因子及预后的影响。方法：选择我院2015年1月—2016年1月接诊的100例急性胰腺炎患者作为研究对象,将患者随机分为观察组和对照组,观察组患者52例,采用清胰汤联合早期微生态肠内营养治疗,对照组患者48例,采用常规的抗感染、抑酸和胰液分泌等肠外营养治疗,分析对比两组患者的血清淀粉酶、炎性细胞因子及预后的情况。结果：观察组的胃肠道功能恢复时间（3.22±0.89）d、腹痛缓解时间（3.12±0.61）d、腹胀缓解时间（3.01±0.74）d、住院时间（27.41±3.15）d和禁食时间（6.50±1.15）d,与对照组相比,明显都短于对照组,差异有统计学意义（P〈0.05）;两组患者经过治疗后,血清淀粉酶、TNF-α、IL-8水平有所下降,IL-10水平有所提高,并且观察组患者与对照组患者相比,其降低和升高的幅度大于对照组,差异有统计学意义（P〈0.05）;观察组经过治疗后,有12例并发症发生,并发症发生率为23.08%,对照组经过治疗后,有38例并发症发生,并发症发生率为79.17%,观察组治疗后的并发症明显更低,预后情况更好,差异有统计学意义（P〈0.05）。结论：急性胰腺炎患者临床上采用清胰汤联合早期微生态肠内营养治疗,能有效促进肠胃功能的恢复,改善患者的营养状况,还能减少并发症发生,降低炎症反应,临床效果较好,值得推广使用。

Objective：To investigate the effect of Qingyi Decoction combined with early micro ecological enteral nutrition on serum amylase,inflammatory cytokines and prognosis in patients with acute pancreatitis. Methods：100 cases of acute pancreatitis in our hospital from January 2015 to January 2016 served as the research object,the patients were randomly divided into observation group and control group,52 patients in the observation group with Qingyi Decoction combined with early enteral microecopharmaceutics nutrition therapy,48 patients in control group were used routine anti infection,anti acid and pancreatic juice secretion of parenteral nutrition in the treatment,comparative analysis of two groups of patients with serum amylase,inflammatory cytokines and prognosis. Results：In the observation group,the recovery of gastrointestinal function（3.22±0.89）d,the abdominal pain（3.12±0.61）d,abdominal distension（3.01±0.74）d,hospitalization（27.41±3.15）d,and fasting time（6.50±1.15）d,compared with the control group,were significantly shorter than the control group,the difference there was statistical significance（P〈0.05）;the two groups of patients after treatment,decrease of serum amylase,TNF-α,IL-8 level,IL-10 level increased,and the patients in the observation group compared with the control group,the lower and higher than in the control group,the difference was statistically significant（P〈0.05）;the observation group after treatment have occurred,12 cases of complications,the complication rate was 23.08%,the control group after treatment,38 cases occurred complications,the complication rate was 79.17%,complication observation group after treatment were significantly lower,prognosis was better,worse The difference was statistically significant（P〈0.05）. Conclusion：Patients with acute pancreatitis,the clinical use of QingyiDecoction combined with early enteral microecopharmaceutics nutrition therapy,can effectively promote the recovery of gastrointestinal function,improve the nutritional status of patients,can reduce complications,reduce inflammation,good clinical effect,worthy of promotion of use.