丹参川芎嗪注射液对急性心肌梗死并发房颤患者血清癌胚抗原CA199水平影响研究

Study on the Effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on Serum Carcinoembryonic Antigen CA199 Levels in Patients with Acute Myocardial Infarction Complicated with Atrial Fibrillation

目的：探讨丹参川芎嗪注射液对急性心肌梗死并发房颤患者血清癌胚抗原CA199水平的影响。方法：选取我院符合标准的急性心肌梗死并发房颤患者88例,为2013年10月—2015年12月的病例。按随机对照设计原则、根据入选标准分为2组,分别为44例,对照组采用胺碘酮治疗,研究组在此基础上采用丹参川芎嗪注射液治疗,共治疗2周。治疗前和治疗后测定所有患者心功能指标,收集所有患者的血液标本测定血浆NT-pro BNP、BNP及血清Hs-CRP、CA199、AFP值,同时对比6 h、6~12 h、12~18 h、18~24 h窦性心律恢复和30 d内窦性心律维持效果。结果：与治疗前比,两组治疗后血浆NT-pro BNP、BNP值降低,血清Hs-CRP、CA199、AFP值降低,LVEF、CO升高,LVEDD、LVESD降低（P〈0.05）;与对照组比,研究组治疗后血浆NT-pro BNP、BNP值较低,血清Hs-CRP、CA199、AFP值较低,LVEF、CO较高,LVEDD、LVESD较低（P〈0.05）;对照组在6 h、6~12 h、12~18 h、18~24 h时窦性心律恢复低于研究组（P〈0.05）;对照组有效率52.27%低于研究组有效率81.82%（P〈0.05）。结论：急性心肌梗死并发房颤采用丹参川芎嗪注射液治疗的效果显著,降低心肌损伤及癌胚抗原CA199水平,改善心功能,且不加重药物不良反应,是一种有效的治疗方案。

Objective：To investigate the effect of Salviae miltiorrhizae and Ligustrazine Hydrochloride Injection on serum carcinoembryonic antigen CA199 levels in patients with acute myocardial infarction complicated with atrial fibrillation. Methods：88 patients with acute myocardial infarction complicated with atrial fibrillation in our hospital were selected,who were from October 2013 to December 2015,according to the randomized control design principle,were divided into 2 groups,44 cases each. The control group were treated with amiodarone treatment,the study group was treated more with Salviae miltiorrhizae and Ligustrazine Hydrochloride Injection,a total of 2 weeks. Heart function were measured in all patients before and after treatment,blood samples were collected from all patients plasma NT-pro BNP and serum HsCRP,BNP,CA199,AFP value,compared with 6 h,6-12 h,12-18 h,18-24 h and 30 d in sinus rhythm restoration of sinus rhythm maintenance. Results：Compared with that before treatment,levels of plasma NT-pro BNP and BNP decreased in two groups after treatment,serum Hs-CRP,CA199,AFP decreased,LVEF,CO increased,LVEDD,LVESD decreased（P〈0.05）. Compared with the control group,the study group after treatment,levels of plasma NT-pro BNP and BNP were lower,serum Hs-CRP,CA199,AFP were lower,LVEF,CO were higher and LVEDD,LVESD were lower（P〈0.05）,the control group in 6 h,6-12 h,12-18 h,18-24 h,sinus rhythm were lower than the group（P〈0.05）,the effective rate in the control group 52.27% was lower than study group 81.82%（P〈0.05）. Conclusion：Atrial fibrillation complicating acute myocardial infarction using Salviae miltiorrhizae and Ligustrazine Hydrochloride Injection treatment has remarkable effect,reduce myocardial injury and carcinoembryonic antigen CA199 levels,improve heart function,without increasing adverse drug reactions,which is an effective treatment plan.