缺铁性贫血患者血清促红细胞生成素水平与血红蛋白的定量相关关系

Quantitative relationship between serum erythropoietin levels and hemoglobin in patients with iron deficiency anemia

目的探讨缺铁性贫血（IDA）患者血清促红细胞生成素（sEPO）水平与血红蛋白（Hb）之间的定量相关关系。方法收集轻、中、重度IDA患者共170例，测定其sEPO及Hb水平，分析sEPO与Hb的相关性并建立回归方程。结果在170例IDA患者中，sEPO与Hb呈较强负相关（r=-0．810，P〈0．001），sEPO与Hb关系的回归方程为sEPO=1084．00—10．68×Hb；轻度IDA组sEPO与Hb的相关性较弱（r=-0．313，P=0．010），回归方程为sEPO=299．30—2．39×Hb，可预测sEPO范围为12．5～84．2IU／L；中度IDA组sEPO与Hb呈较明显负相关（r=-0．519，P〈0．001），回归方程为sEPO=1063．07—11．25×Hb，可预测sEPO范围为50．57～388．07IU／L；重度IDA组sEPO与Hb呈较明显负相关（r=-0．495，P=0．006），回归方程为sEPO=1310．97—13．44×Hb，可预测sEPO范围为504．57～750．00IU／L。结论IDA患者sEPO与Hb水平存在定量相关关系，可通过预测不同程度IDA患者sEPO水平为其鉴别诊断和治疗提供依据。

Objective To investigate the quantitative relationship between serum erythropoietin （sEPO） levels and hemoglobin（Hb） in iron deficiency anemia（IDA） patients. Methods A total of 170 patients with mild, moderate and severe IDA were collected. The levels of sEPO and Hb were measured, the correlation between sEPO and Hb levels was analyzed and a regression equation was established. Results In 170 patients with IDA, there was a strong negative correlation between sEPO and Hb （ r = - 0. 810 ,P 〈 0.001 ）. The regression equation between sEPO and Hb was sEPO = 1 084. 00 - 10. 68 × Hb. In mild IDA group,the correlation between sEPO and Hb was weak （r = -0. 313, P = 0. 010）. The regression equation was sEPO =299.30 - 2.39 × Hb and the predictable range was 12.5-84.2 IU/L. In moderate IDA group, sEPO and Hb showed obvious negative correlation （ r = - 0. 519, P 〈 0. 001 ）. The regression equation was sEPO = 1 063.07 - 11. 25 × Hb and the predictable range was 50.57-388.07 IU/L. The correlation between sEPO and Hb in severe IDA group was significantly negatively correlated （r= -0. 495,P = 0. 006）. The regression equation was sEPO = 1 310. 97 - 13. 44× Hb and the predictable range was 504.57-750.00 IU/L. Conclusion There is a quantitative correlation between sEPO and Hb levels in patients with IDA ,which provides evidence for differential diagnosis and treatments by predicting the sEPO level of IDA patients.