高脂血症性及非高脂血症性急性胰腺炎患者的临床特点与C-反应蛋白对其严重程度的评估

Clinical characteristics of hyperlipidemic acute pancreatitis and nonhyperlipidemic acute pancreatitis and C-reactive protein in assessment of its severity

目的探讨高脂血症性急性胰腺炎及非高脂血症性急性胰腺炎的临床特点及C-反应蛋白(CRP)对其严重程度的评估价值。方法选择于2012年1月-2016年12月期间医院收治的高脂血症性急性胰腺炎患者80例为高脂血症组和非高脂血症性急性胰腺炎患者80例为非高脂血症组。统计分析患者的年龄、性别、腹痛持续时间、腹痛至入院间隔时间、住院天数、合并症等临床资料,使用全自动生化分析仪测定血清CRP水平。观察分析两组患者的临床特点及CRP水平。结果高脂血症组住院时间短于非高脂血症组,高脂血症组男性、脂肪肝、糖尿病、急性胰腺炎复发均高于非高脂血症组,高脂血症组轻度急性胰腺炎低于非高脂血症组(P<0.05);高脂血症组第1、3、5、7天血清CRP水平分别为(51.21±18.57)mg/L、(195.46±64.35)mg/L、(121.35±46.57)mg/L、(64.25±18.54)mg/L,均高于非高脂血症组(P<0.05);第1、3、5、7天,轻度、中度、重度急性胰腺炎的高脂血症组血清CRP水平与非高脂血症组比较均差异有统计学意义(P<0.05)。结论高脂血症性急性胰腺炎发病年龄较轻,合并症多,复发率高,高脂血症性急性胰腺炎和非高脂血症性急性胰腺炎不同严重程度患者中CRP水平差异不同。

OBJECTIVE To investigate the clinical characteristics of hyperlipidemic acute pancreatitis and non-hyperlipidemic acute pancreatitis and the value of C-reactive protein in assessing its severity.METHODS A total of 80 patients with hyperlipidemic acute pancreatitis were selected as hyperlipidemia group and 80 patients with non-hyperlipidemic acute pancreatitis were selected as nonhyperlipidemia group from Jan.2012 to Dec.2016.The clinical data of age,gender,duration of abdominal pain,interval time of abdominal pain to admission,days of hospitalization and complications were statistically analyzed,and serum C-reactive protein levels were determined by automatic biochemical analyzer.The clinical characteristics and CRP levels of the two groups of patients were observed and analyzed.RESULTS The length of hospital stay in hyperlipidemia group was shorter than that in non-hyperlipidemia group（P0.05）.The recurrence rates of male,fatty liver,diabetes mellitus and acute pancreatitis in hyperlipidemia group were higher than those in non-hyperlipidemia group（P0.05）.The levels of serum CRP at 1,3,5 and 7 dof hyperlipidemia group were（51.21±18.57）mg/L,（195.46±64.35）mg/L,（121.35±46.57）mg/L and（64.25±18.54）mg/L,respectively,which were higher than those of non-hyperlipidemia group（P0.05）.The levels of serum CRP at 1,3,5 and 7 dof hyperlipidemia group of mild,moderate and severe acute pancreatitis had significant differences compared with those of non-hyperlipidemia group（P0.05）.CONCLUSION The age of patients with hyperlipidemia acute pancreatitis is low,with many complications and high recurrence rate.The C-reactive protein levels in patients with hyperlipidemia acute pancreatitis and non-hyperlipidemic acute pancreatitis with different severities are different.