经血栓抽吸导管注射替罗非班与硝酸甘油对急诊PCI术中无复流的影响

Effect of intravenous infusion of tirofiban and nitroglycerin via thrombus aspiration catheter on the no-flow phenomenon in emergency PCI

目的观察经血栓抽吸导管注射替罗非班联合硝酸甘油对急诊经皮冠脉介入治疗(PCI)术中无复流的影响。方法将26例术中发生冠脉无复流现象患者随机分为14例血栓抽吸导管组(A组)和12例指引导管组(B组),观察并记录两组患者术前、后的心肌梗死溶栓(TIMI)血流分级、校正TIMI帧数(CTFC)和左心室射血分数(LVEF)。结果 A组治疗后的TIMI分级显著高于B组(Hc=5.451,P<0.05),CTFC和LVEF水平显著低于B组(P<0.05)。结论急诊PCI术中经血栓抽吸导管注射替罗非班联合硝酸甘油治疗可有效恢复冠脉血流和心肌灌流。

Objective To investigate the effect of intravenous infusion of tirofiban and nitroglycerin via thrombus aspiration catheter on the no-flow phenomenon in emergency PCI.Methods 26 patients with intraoperative no-flow phenomenon were randomly divided into the Thrombus Aspiration Catheter Group（14 cases）and the Guided Catheter Group（12 cases）.The myocardial infarction thrombolysis（TIMI）flow grade,corrected TIMI frame number（CTFC）and left ventricular ejection fraction（LVEF）of the two groups were observed and recorded before and after operation.Results The TIMI grade of the Thrombus Aspiration Catheter Group was significantly higher that of the Guided Catheter Group（Hc=5.4507,P〈0.05）,and the level of CTFC and LVEF of the Thrombus Aspiration Catheter Group was significantly lower than that of the Guided Catheter Group（P〈0.05）.Conclusion the intravenous infusion of tirofiban and nitroglycerin via thrombus aspiration catheter in emergency PCI can effectively restore coronary blood flow and myocardial perfusion.