白细胞介素35在器官移植免疫中的研究进展

Research progress on interleukin 35 in organ transplantation immunity

白细胞介素35(IL-35)是近年发现并命名的IL-12家族细胞因子,它可由调节性T(Treg)细胞和调节性B(Breg)细胞特异性产生,是Treg和Breg细胞介导的负向免疫调节作用所必需的细胞因子。研究表明IL-35在器官移植免疫中发挥重要作用,针对IL-35的临床研发药物及细胞药物治疗可为抗移植排斥反应甚至诱导移植免疫耐受提供新的靶点和研究方向。

Interleukin 35（IL-35） is a kind of cytokine which is recently found and belongs to the IL-12 family. IL-35 is a cytokine secreted by regulatory T cells（Treg） and regulatory B cells（Breg）, and is necessary for the negative immunoregulation mediated by Treg and Breg cells. Studies have shown that IL-35 plays an important role in organ transplantation immunity. The clinical research development drugs and cell therapy drugs for IL-35 can provide new targets and research directions for anti-graft rejection and even induction of transplantation immunity tolerance.