重症手足口病患儿预后特点及影响因素分析

Survey analysis on characteristics and correlated risk factors of prognosis of children severe hand foot and mouth disease

目的探讨重症手足口病患儿预后的特点及其影响因素。方法选取124例重症手足口病患儿,依据其预后分为86例预后良好组和38例预后不良组;采用单因素比较法和多因素logistic回归法筛选影响患儿预后的相关危险因素。结果多因素logistic回归分析结果显示,不典型皮疹(OR=2.370)、抽搐(OR=3.725)、肺部渗出性病变(OR=3.522)、循环障碍(OR=6.240)及白细胞计数(OR=1.972)等因素为重症手足口病患儿预后不良的危险因素。结论重症手足口病患儿病情进展较为迅速,其预后效果较差,影响其预后的独立危险因素包括不典型皮疹、反复抽搐、肺部渗性病变、循环障碍及白细胞计数升高等,应针对这些因素采取相应干预措施。

Objective To explore the characteristics and correlated risk factors of prognosis of children server hand foot and mouth disease. Methods Totally 124 children with server hand foot and mouth disease were chose and divided into good prognosis group （86 cases） and poor prognosis group （38 cases）. The methods of single factor comparison and multiple factors Logistic regression were used to screen the risk factors of prognosis of the children. Results Multiple factors Logistic regression analysis result showed that atypical eruption （ OR = 2. 370）, convulsion （ OR = 3. 725 ）, pulmonary exudative lesions （ OR = 3. 522）, disturbance of cireulaton （ OR = 6. 240） and lencocyte count （ OR = 1. 972） were risk factors of poor prognosis of children with server hand foot and mouth disease. Conclusion There is a high incidence rate of poor prognosis of children with server hand foot and mouth disease. The independent risk factors include atypical eruption, recurrent tic, exudative lesions, disturbance of eirculaton and high level of lencocyte count. We should adopt corresponding intervention measures to aim directly at these risk factors.