感染性疾病内皮活化/功能障碍的生物标记物的研究进展

Research Progress of the Biomarkers for Endothelial Activation/dysfunction in Infectious Diseases

内皮功能障碍在脓毒症、重症疟疾及登革出血热等多种感染性疾病发病机制中起着重要作用。由于内皮活化常先于内皮功能障碍,血清或/血浆中相应内皮生物标记物常较传统疾病标记物更早被检测到,故可作为评估全身感染性疾病严重程度或预后的指标。本文主要介绍了内皮细胞功能介质(血管生成素-1和血管生成素-2)和可溶性细胞表面黏附分子(可溶性E-选择素、sICAM-1和sVCAM-1)在脓毒症、疟疾及登革出血热等疾病中的表达及临床意义。

Endothelial dysfunction plays an important role in the pathogenesis of multiple infectious diseases, such as sepsis,severe malaria and dengue hemorrhagic fever. Because endothelial activation usually precedes overt endothelial dysfunction, the corresponding endothelial biomarkers in serum or plasma can be detected earlier than those of the routine disease markers, and therefore,can be considered as parameters evaluating disease severity or prognosis of infectious diseases. In this review, the expression and clinical significance of endothelial cell functional mediators（angiopoietin-1 and angiopoietin-2） and soluble cell surface adhesion molecules（soluble E-selectin, sICAM-1 and sVCAM-1） is discussed in sepsis, malaria and dengue hemorrhagic fever.