海藻酸钠/壳聚糖微载体的研究进展

Progress in research on sodium alginate/chitosan microcarriers

海藻酸钠(sodium alginate,SA)是从褐藻类中提取的一种具有生物活性、可生物降解的聚阴离子电解质;壳聚糖(chitosan,CS)是一种天然的、含有氨基的亲水性多糖,是一种聚阳离子电解质。SA/CS微载体是一种天然的高分子材料,具有无毒性、生物相容性、生物降解性,且能够与生物大分子药物结合,使其所载药物可缓慢且稳定地释放,从而实现药物的靶向作用,因此SA/CS微载体在生物医学领域具有广阔的应用前景。本文就SA/CS微载体的生物特性、制备方法、体外释放特性及其作为药物载体的相关应用作一综述。

Sodium alginate（SA）is a bioactive and biodegradable polyanion electrolyte extracted from phaeophyta,while chitosan（CS） is a natural hydrophilic polysaccharide containing amino group,which is a polycation electrolyte. SA/CS microcarrier is a natural macromolecule material which is non-toxic,biocompatible,biodegradable and capable of binding to biomacromolecules to release the drugs stably and slowly. There,the microcarrier is of a broad prospect of application in biomedical field. In this paper,the biological characteristics,preparation methods,in vitro release characteristics and application of of SA/CS microcarrier as a drug carrier are reviewed.