强直性脊柱炎伴发高血尿酸患者的临床特征及疾病活动度研究

The analysis of clinical characteristics and disease activity in ankylosing spondylitis patients with hyperuircemia

目的 探索强直性脊柱炎（AS）伴发高血尿酸患者的临床特征及疾病活动度。方法 采集2015年9月至2017年10月间复旦大学附属中山医院门诊AS患者的临床资料、实验室检查、磁共振成像及病情活动及功能评估。通过t检验、χ2检验分析高尿酸组与正常尿酸组AS患者临床特征及疾病活动度之间的差异。结果 23.4%（22/94）AS患者合并高尿酸血症。与正常尿酸患者相比，伴有高尿酸血症的AS患者年龄更小（28.9岁±7.9岁比35.8岁±11.1岁，P＝0.002）、丙氨酸氨基转移酶（33.6 U/L±23.6 U/L比19.8 U/L±12.4 U/L, P＝0.014）、门冬氨酸氨基转移酶（23.8 U/L±8.7 U/L比18.6 U/L±9.6 U/L, P＝0.025）、肌酐（78.4 μmol/L±12.5 μmol/L比69.8 μmol/L±13.3 μmol/L, P＝0.009）水平更高，Bath强直性脊柱炎病情活动指数（BASDAI）（11.2±8.8比17.9±12.0, P＝0.027）及Bath强直性脊柱炎功能指数（BASFI）（0.7±0.9比1.8±2.2, P＝0.002）更低。结论 年龄更小、肝肾功能受损及BASDAI、BASFI更低的AS患者更易合并高尿酸血症。

Objective to investigate the clinical characteristics and disease activity in ankylosing spondylitis （AS） patients with hyperuricemia.Method Laboratory tests, magnetic resonance imaging, disease activity and functional index of AS patients from Fudan University Zhongshan Hospital were collected. T test, square test were applied to investigate the difference between AS patients with hyperuricemia and AS patients with normal serum uric acid in clinical characteristics and disease activity in AS patients.Result Among all the AS patients, 23.4% （22/94） patients accompanied with hyperuricemia. AS patients accompanied with hyperuricemia showed significant younger age （28.9±7.9 vs 35.8±11.1, P=0.002）; higher serum alanine aminotransferase （33.6±23.6 vs 19.8±12.4, P=0.014）, aspartate aminotransferase （23.8±8.7 vs 18.6±9.6, P=0.025） and creatinine （78.4±12.5 vs 69.8±13.3, P=0.009）, lower Bath Ankylosing Spondylitis Disease Activity Index （BASDAI） （11.2±8.8 vs 17.9±12.0, P=0.027） and Bath Ankylosing Spondylitis Functional Index （BASFI） （0.7±0.9 vs 1.8±2.2, P=0.002） compared with AS patients whose serum uric acid level is normal.Conclusion AS Patients with younger age, impaired hepatic and renal funtion and lower scores in BASDAI and BASFI tend to accompany with hyperuricemia.