幽门螺杆菌感染与口腔扁平苔藓相关性Meta分析

ASSOCIATION BETWEEN HELICOBACTER PYLORI INFECTION AND ORAL LICHEN PLANUS:A META-ANALYSIS

目的探讨幽门螺杆菌感染与口腔扁平苔藓发生的病因学关系。方法计算机检索中国期刊全文数据库(CNKI)、维普学术期刊数据库(VIP)、万方学术期刊数据库、Pubmed数据库,筛选之后纳入幽门螺杆菌感染与口腔扁平苔藓关系的相关文献,对所得数据进行Meta分析。结果入选的9项研究之间存在异质性(I2=87.5%,P<0.01)。Meta分析显示,口腔扁平苔藓病人幽门螺杆菌感染率(47.51%)明显高于对照组(29.54%),差异有统计学意义(Z=2.81,P<0.05)。回归分析显示,不同检测方法不是异质性来源的因素,不同来源地区是异质性来源的因素。亚组分析显示,不同来源地区对结果会产生影响。结论幽门螺杆菌感染与口腔扁平苔藓的发生可能存在相关性。

Objective To investigate the association between Helicobacter pylori infection and oral lichen planus from the aspect of etiology. Methods CNKI,VIP,Wanfang Data,and PubMed were searched for articles on the association between Helicobacter pylori infection and oral lichen planus. Results A total of 9 studies were included,and there was heterogeneity between them（I2=87.5%,P〈0.01）.The Meta-analysis showed that the oral lichen planus group had a significantly higher Helicobacter pylori infection rate than the control group（47.51% vs 29.54%,Z=2.81,P〈0.05）.The regression analysis showed that different detection methods were not factors for heterogeneous sources,while different areas were factors for heterogeneous sources.The subgroup analysis showed that different areas had certain influence on results. Conclusion Helicobacter pylori infection may be associated with the development of oral lichen planus.