外周血中性粒细胞计数变化与突发性聋患者预后的关系

The relationship between peripheral blood neutrophil count and prognosis of patients with sudden deafness

目的探讨突发性聋患者外周血中性粒细胞水平与患者预后的关系。方法将160例突发性聋患者进行纯音听阈测定听力损失，分型进行治疗，同时治疗前和治疗中每隔一天检测血常规中性粒细胞水平，按治疗前中性粒细胞水平分为高水平组和低水平组，记录两组患者中性粒细胞水平变化，对患者进行预后评估。结果突发性聋患者分型治疗后其总有效率为70．64％，治疗前有72例患者外周血中性粒细胞水平偏高，并且其随着治疗的进行逐渐降低为正常范围。将外周血中性粒细胞高水平组和低水平组进行预后比较，发现高水平组总有效率为38，85％，而低水平组总有效率为31．79％，差异有统计学意义（χ^2=9．194，P〈0．01）。结论突发性聋患者治疗前外周血中性粒细胞水平越高，患者预后效果越好。

Objective To investigate the relationship between peripheral blood neutrophil levels and prognosis in patients with sudden deafness. Methods 160 patients with sudden deafness were treated with pure tone hearing threshold to determine hearing loss, type of treatment, before treatment and treatment every other day the blood neutrophil level was detected. According to the level of neutrophil before treatment, the patients were divided into high - level group and low - level group. The neutrophil levels in two groups were recorded, and the prognosis of patients was analyzed. Results The total effective rate was 70, 64% in patients with sudden deafness after treatment, and 72 patients had high level of neutrephil in the peripheral blood before treatment, and gradually decreased to normal range as the treatment progressed, The prognosis of peripheral blood neutrophils in high - level group and low - level group was compared,we found that the total effective rate was 38.85% in the high level group and 31.79% in the low level group, and the high - level group had a better prognosis than the low - level group, the difference was statistically significant（ χ^2 = 9. 194,P 〈0.01 ）. Conclusion The higher the level of neutrophils in patients with sudden deafness before treatment, the better the prognosis of patients.