玻璃酸钠关节腔注射配合口服阳和汤治疗膝骨关节炎的疗效分析

Analysis of therapeutic effect of sodium hyaluronate intra - articular injection combined with oral Yanghe decoction in the treatment of knee osteoarthritis

目的探讨玻璃酸钠关节腔注射配合口服阳和汤治疗膝骨关节炎的疗效。方法将80例膝骨关节炎患者采用随机数字表法分为两组，每组40例。对照组患者给予玻璃酸钠关节腔注射，研究组患者则加服阳和汤，比较两组患者中医症状评分、膝关节指标、总体治疗效果与生活质量。结果研究组患者治疗后中医症状总分为（7．08±1．18）分，显著低于对照组的（10．42±2．01）分（t=9．063，P〈0．01）；研究组治疗后疼痛视觉模拟评分和骨关节炎指数评分分别为（1．48±0．59）分、（19．10±3．08）分，均显著低于对照组的（3．70±1．12）分、（23．40±3．56）分（t=11．091、5．777，均P〈0．01）；研究组治疗后膝关节功能评分为（83．04±10．49）分，显著高于对照组的（71．81±9．67）分（t=4．978，P〈0．01）；研究组治疗6个月后生理机能、生理职能、躯体疼痛、精神健康与精力评分均显著高于对照组（t=5．190、8．535、4．569、3．266、6．694，均P〈0．01）；研究组显效率和总有效率分别为72．5％、95．0％，均明显高于对照组的50．0％、77．5％，差异均有统计学意义（χ^2=4．266、5．165，均P〈0．05）。结论玻璃酸钠关节腔注射配合口服阳和汤治疗膝骨关节炎的疗效显著。

Objective To investigate the curative effect of sodium hyaluronate intraperitoneal injection combined with oral Yanghe decoction in the treatment of knee osteoarthritis. Methods 80 patients with knee osteoar-thritis were randomly divided into two groups ,40 cases in each group. The control group was given intraarticular injection of sodium hyaluronate, and the study group was treated with Yanghe decoction in addition. The TCM symptom score , knee joint index , overall treatment effect and quality of life were compared between the two groups . Results The total score of TCM symptoms after treatment in the study group was （7.08 ± 1.18 ） points, which was significantly lower than （ 10.42 ± 2. 01） points in the control group（ t = 9.063 ,P 〈 0.01 ）. The VAS score and WOMAC score after treatment in the study group were （ 1.48 ± 0.59） points, （ 19.10±3.08） points, respectively, which were significantly lower than （3.70 ± 1.12） points and （23.40 ± 3.56） points in the control group （ t = 11.091,5. 777, all P 〈 0.01 ）. The HSS score after treatment in the study group was （83.04 ± 10.49）points,which was significantly higher than （71.81 ± 9.67 ） points in the control group （ t = 4： 978, P 〈 0. 01 ）. The physiological function, physical function, physical pain,mental health and energy scores after 6 months treatment in the study group were significantly higher than those in the control group （t =5. 190,8,535,4. 569,3. 266,6. 694, all P 〈0.01 ）. The effective rate and total effective rate of the study group wore 72.5% and 95.0% ,respectively,which were significantly higher than those of the control group（50.0% ,77.5% ）, the differences were statistically significant （χ^2 = 4. 266,5. 165, all P 〈 0.05 ）. Conciusion Sodium hyaluronate injection combined with oral Yanghe decoction is effective in the treatment of knee osteoarthritis.