制川乌粉体粒径与其破壁率和溶出度的相关性研究

Study on the correlation between the particle size and cell - wall breaking ratio, dissolution rate of Zhichuanwu powder

目的探讨制川乌粉体粒径与其破壁率和溶出度的相关性。方法采用光学显微镜测定4种制川乌粉体（40目、60目、80目和300目）的粒径、细胞破壁率；采用桨法考察上述4种粉体的溶出特征。结果不同粉碎程度的制川乌粉体的粒径分布、破壁率和溶出度相关性强，0-15h内，随着制川乌分体粒径的增加，溶出率由81．2％上升至90．5％，表明随着粉体粒径的减小细胞破壁率和溶出率提高。结论适度的改变粉碎程度可提高制川乌细胞破壁率和有效成分溶出的速率和程度。

Objective To study the correlation between the particle size and cell - wall breaking ratio, dissolution rate of Zhichuanwu powder. Methods The particle size and cell breaking rate of four kinds of Chuanwu powder （40 mesh ,60 mesh,80 mesh and 300 mesh） were determined by optical microscope. The dissolution characteristics of the above four kinds of powders were investigated by paddle method. Results The results showed that the particle size distribution, fracture rate and dissolution rate of the Chuanwu powder were different, within 0- 15 hours, with the increase of particle size of the prepared aconite root divided, the dissolution rate increased from 81.2% to 90.5%, and the cell breaking rate and dissolution rate increased with the decrease of the particle size. Conclusion Moderate changes in the degree of crushing can improve the rate of cell - wall breaking and rate of dissolution of active cells.