精神分裂症与酒精使用障碍共患病研究综述

Comorbidity of schizophrenia and alcohol use disorder: A review

酒精使用障碍是精神分裂症最常见的共患病之一。本文回顾了精神分裂症共患酒精使用障碍的评估诊断工具及临床(流行病学、临床特点、治疗与干预)和基础(病因、遗传学、神经发育、神经生物化学、影像学)等方面的研究进展,认为精神分裂症共患酒精使用障碍在病因、诊疗、影像学及神经生物学方面的研究不足,且相关研究结论不一致。因此,在精神分裂症共患酒精使用障碍的病因、诊疗评估、治疗干预及神经生物化学方面需要进一步的深入研究。

Alcohol use disorder is one of the most common comorbidity of schizophrenia. The article reviews the assessment tools and clinical research （prevalence, clinical characteristics and treatment） and fundamental research （etiology, genetics, neurodevelopmental theory, neurobiochemistry, iconography） of schizophrenia with alcohol use disorder according to related articles. The findings suggested that there was lack of researches on etiology, treatment, iconography and neurobiochemistry of schizophrenia with alcohol use disorder and the conclusions were inconformity. Thus, the future research should do further explore inetiology, treatment and neurobiochemistry of schizophrenia with alcohol use disorder.