胶原性结肠炎的研究进展

Research Progress of Collagenous Colitis

胶原性结肠炎是显微镜下结肠炎的一种分型，中老年人多见，尤其女性，以慢性水样腹泻，结肠镜检查阴性，病理活检提示结肠黏膜上皮下胶原带增厚为主要特征。病程一般可持续数月或数年，严重影响患者生活质量。近年来，其发病率持续增高，故本文对胶原性结肠炎的发病机制、诊断依据和治疗措施做一综述。

Collagenous colitis is one of the two main types of microscopic colitis, which predominantly affects middle - aged and elderly women. It is characterized by the presence of chronic watery diarrhea, negative colonoscopy and characteristic histopathol- ogy findings of a thickened layer of sub - epithelial collagen. Course of the disease lasts for several months to years, seriously affecting people＇ squality of life. In recent years, its incidence continues to increase. This paper will review the pathogenesis, diagnosis and treatment of collagenous colitis.